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Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. Myocardial Infarction MI is most commonly due to occlusion blockage of a coronary artery following the rupture of a vulnerable atherosclerotic plaque.
It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process, human resistin, is a Interleukin-6 IL-6 is a pro-inflammatory cytokine, it secreted by T cells and journao to stimulate immune response.
Majaad Hadef D.
El-Yassin Manal k. IL-6 is a cytokine one of a class of immune system regulators it plays a role, in acute phase inflammatory response to cellular injury.
Human Resistin gene is expressed in pancreatic isletspre- adipocytes and bone marrow and is of relevance for inflammation processes.
To investigate serum concentration of resistin and pro inflammatory IL-6 in T1DMchildren and to study the impact jlurnal the duration of disease on these parameter.
Amel Ait Kaki El-Hadef El-Okki
Sixty diabetes hxdef 33 males and 27 femalesaged 1. Duration of disease varied from 0. Age matching group of thirty healthy volunteer children18 females ,12 males was included as a control without any family history of diabetes.
Fasting serum Resistin levels were lower in patients compared to controls although the correlation was not significant. However serum resistin levels were higher in females compared to males in both groups patients and controls with a significant correlation between the groups of the same gender.
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Duration of the disease had no impact hsdef either gender. On the other hand IL-6 showed a significantly higher serum level in patients than control.
Un like Resistinthe duration of disease had a great impact on IL-6 serum levels as shown in text. Resistin antagonizes insulin action, leading to decrease in patients more than controls.
Keywords resistin IL-6 in type 1diabetes mellitus. Listing 1 – 2 of 2.