hospital in Veracruz, MexicoCorrelación de los niveles de alfafetoproteína sérica preoperatoria y sobrevida en el tratamiento quirúrgico del hepatocarcinoma. Os pacientes foram divididos em dois grupos de acordo com o nível de alfa- fetoproteína (menor ou maior que ng/ml. O método de Kaplan-Meier foi usado. Estas moléculas, cuya concentración sérica también depende de la . gonadotropina coriónica humana (HCG) en , alfa-fetoproteína (AFP) en
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Its pages are open to the members of the Association, as well as to all members of the medical community interested in using this forum to publish their articles in accordance with the journal editorial policies. The principal aim of the journal is to publish original work in the broad field of Gastroenterology, as well as to provide information on the specialty and related areas that is up-to-date and relevant.
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The scientific works include the areas of Clinical, Endoscopic, Surgical, and Pediatric Gastroenterology, along with related disciplines. The journal accepts original articles, scientific letters, review articles, clinical guidelines, consensuses, editorials, letters to the Editors, brief communications, and clinical images in Gastroenterology in Seriac and English for their publication. CiteScore measures average citations received per document published.
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SJR uses a similar algorithm as the Google page rank; it provides a alfafetoprogeina and qualitative measure of the journal’s impact.
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival.
Our aim was to analyze alfafeotproteina correlation between preoperative aofafetoproteina alpha-fetoprotein levels and survival, following the surgical treatment of hepatocellular carcinoma. An ROC curve was created to determine the sensitivity and specificity of alpha-fetoprotein in relation to survival Kaplan-Meier. Of the 19 patients evaluated, The mean patient age was The alpha-fetoprotein cutoff point was Preoperative alpha-fetoprotein levels below Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.
Diecinueve pacientes fueron seguidos prospectivamente julio del enero del El punto de corte de AFP fue Los niveles preoperatorios de AFP menores de A cohort of patients with HCC at our hospital that underwent resection as surgical treatment were prospectively followed within the time frame of July and Januaryafter prior authorization from the local ethics and research committee.
Patients were excluded that underwent other surgical treatments local ablation, chemoembolization, transplant, chemotherapy, and no treatment. Age, sex, body mass index, cirrhosis, viral hepatitis, Child-Pugh classification, 10 and the model for end-stage liver disease MELD score were registered. Intensive care unit stay, hospital stay, postoperative liver failure, and perioperative mortality were documented. Follow-up was conducted through outpatient consultations.
Tumor recurrence was defined as the seerica of new radiologic lesions, and survival was calculated from the beginning of the patient’s evaluation up to his or her death or follow-up loss. The continuous variables were described through mean, standard deviation, and range and the categorical variables were described through frequency and percentage.
A receiver operating characteristic ROC curve was plotted to determine the area under the curve, cut-off point, and sensitivity and specificity of preoperative AFP levels for survival in all the patients, calculated using the Kaplan-Meier estimator. In addition, the positive predictive value and negative predictive value of the ROC curve cut-off point were determined for all the patients. Alfafetoprotein regression was carried out with the different AFP levels to determine the survival risk in those patients.
Fifty-two patients were diagnosed with HCC during the study period.
Twelve of those patients received no treatment, 14 underwent radiofrequency ablation, 2 had transarterial chemoembolization, and 5 received chemotherapy sorafeniball of whom were excluded from the analysis.
The study cohort was made up of the remaining 19 patients that underwent resection and The mean age of the study patients was A total of The etiology of liver damage without alfadetoproteina in the remaining ssrica was determined in 8 of them 4 with nonalcoholic steatohepatitis and 4 with alcoholic steatohepatitis.
The mean AFP level was The mean lesion size was 6. Mean hospital stay was 8. One patient died due to postoperative liver failure and another from a cerebrovascular event. Four patients presented with recurrence mean 6. The estimated overall survival was The ROC curve established an area under the curve of 0.
A Survival in relation to preoperative AFP of Our results confirmed the relation of preoperative serum AFP levels to survival in patients that underwent liver resection as HCC treatment.
Different studies suggest the relation of an elevated preoperative serum AFP level to the prediction of recurrence, survival, and outcome in HCC. Likewise, Wen-Jun et al. Our group 9 previously reported that patients that underwent liver resection had lower AFP levels than other patients, which led to the development of the present study.
Those findings must be corroborated in other case series with different population characteristics. The authors declare that no experiments were performed on humans or animals for this study.
The authors declare that no patient data appear in this article. The authors alfafdtoproteina that there is no conflict of interest. Please cite this article as: Previous article Next article.
October – December Pages Correlation between preoperative serum alpha-fetoprotein levels and survival with respect to the surgical treatment of hepatocellular carcinoma at a tertiary care hospital in Veracruz, Alfafteoproteina.
This item has received. Under a Creative Commons license. Introduction Preoperative serum alpha-fetoprotein levels can have predictive value for hepatocellular carcinoma survival.
Aim Our aim was to analyze the correlation between preoperative serum alpha-fetoprotein allfafetoproteina and survival, following the surgical treatment of hepatocellular carcinoma. An ROC curve was created to determine the sensitivity and specificity of alpha-fetoprotein in relation to survival Kaplan-Meier. Results Of the 19 patients evaluated, Conclusions Elevated preoperative serum alpha-fetoprotein levels have predictive value for hepatocellular carcinoma survival.
Materials and methods A cohort of patients with HCC at our hospital that underwent resection as surgical treatment were prospectively followed within the time frame of July and Januaryafter prior authorization from the local ethics and research committee. Tumor recurrence was defined as the appearance of new radiologic lesions, and survival was calculated from the beginning of the patient’s evaluation up to his or her death or follow-up loss. Statistical analysis The continuous variables serifa described through mean, standard deviation, and range and the categorical variables were described through frequency and percentage.
Results Fifty-two patients were diagnosed with HCC during the study period. The continuing increase in the incidence of hepatocellular carcinoma in the United States: Mortality trends for liver cancer in Mexico from to Management of hepatocellular carcinoma.
Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma. Clinical characteristics and prognosis of hepatocellular carcinoma: Analysis based on serum alpha-fetoprotein levels. Correlation analysis of preoperative serum alpha-fetoprotein AFP level and prognosis of hepatocellular carcinoma HCC after hepatectomy.
World J Surg Oncol. Modalidades de tratamiento para pacientes con carcinoma hepatocelular: Gastroenterol Hepatol, 27pp. Subscribe to our Newsletter. Presentation, staging, and outcome alfafetoprotelna patients with Mexican consensus on the diagnosis and management of Liver resection morbidity, mortality, and risk factors at Si continua navegando, consideramos que acepta su uso.
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